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TB LAMP Application Examples
The demand for molecular test in TB diagnosis
Molecular diagnostic tests offer an important, rapid, and under-utilized molecular tool in TB (tuberculosis) diagnosis. These tests detect mycobacteria with high specificity by amplifying target nucleic acid sequences. WHO recommends that a molecular diagnostic test be performed on the first sputum sample of all suspected TB patients regardless of smear results [*1].
Innovative Tool “TB LAMP”
TB LAMP is a manual molecular test to detect Mycobacterium Tuberculosis complex (MTBC).
It takes less than 1.5 hours to perform, requires minimal instrument in the form of a heating block, and generates a fluorescent result that can be detected with the naked eye.
Additionally, it has the potential for higher throughput as it can test up to 14 samples per test run (max. 70 samples per day). TB LAMP which is a simple, accurate, robust and affordable test, has been developed for use in high burden and resource limited settings.
WHO recommendation [*1]
WHO recommends that TB LAMP may be used as a replacement for microscopy for the diagnosis of pulmonary TB in adults with signs and symptoms of TB. TB LAMP may also be considered as a follow-on test to microscopy in adults with signs and symptoms of pulmonary TB, especially when further testing of sputum smear-negative specimens is necessary. Cost effectiveness of TB LAMP is also mentioned in the policy guidance from WHO.
Examples of using TB LAMP
Case of Cameroon
“TB-LAMP in Cameroon: Two Years After – Results and Lessons Learned” by DONKENG DONFACK Valerie Flore (PhD). Centre Pasteur du Cameroun, (Mycobacteriology unit, NRL-TB, NTP)
World TB Day - Special video "TB-LAMP A new tool to improve Tuberculosis diagnosis in Cameroon"
Case of Zambia
“Evaluation and piloting of TB LAMP assay for the diagnosis of PTB in Lusaka” by Eddie Samuneti Solo(BSC, MPH)
Case of the Philippines
“From Research to Policy to Implementation: The TB-LAMP Experience in The Philippines” by Rosarie Villabito Gabuya, MHSS, RN. Department of Health, Research Institute for Tropical Medicine, National Tuberculosis Reference Laboratory
Case of India
“Harnessing the advantages of TB-LAMP in India’s private healthcare sector” by Dr. Shalabh Malik, MD National Head Microbiology & Molecular Department
“TB -LAMP: New validation study and its importance to find the “missing millions” by Dr. Sunil Sethi, Professor, Department of Medical Microbiology. Post Graduate Institute of Medical Education & Research, Chandigarh
Cases of Cameroon, Nigeria and Viet Nam: The Union Custom Webinar
The recorded webinar is available on The Union Courses Online.
Date : 10th November 2021.
Webinar title: TB diagnosis as a first step of TB elimination: Efficacy and challenges using TB-LAMP.
Moderated by Dr. Satoshi MITARAI, Japan Anti-Tuberculosis Association.
Presentations:
- "A cost-benefit algorithm for rapid diagnosis of Tuberculosis and Rifampicin resistance detection during mass screening campaigns", by Dr. Valérie DONKENG, The Pasteur Centre in Cameroon
- "The Roll out of TB-LAMP Diagnostics in Nigeria: KNCV experience", by Dr. Nkiru NWOKOYE, KNCV Tuberculosis Foundation Nigeria
- "The Expansion of the TB-LAMP Application to HIV/TB Co-infections", by Dr. Nguyen Van HUNG, National Lung Hospital, Viet Nam
Webinar title: TB diagnosis as a first step of TB elimination: Efficacy and challenges using TB-LAMP.
Moderated by Dr. Satoshi MITARAI, Japan Anti-Tuberculosis Association.
Presentations:
- "A cost-benefit algorithm for rapid diagnosis of Tuberculosis and Rifampicin resistance detection during mass screening campaigns", by Dr. Valérie DONKENG, The Pasteur Centre in Cameroon
- "The Roll out of TB-LAMP Diagnostics in Nigeria: KNCV experience", by Dr. Nkiru NWOKOYE, KNCV Tuberculosis Foundation Nigeria
- "The Expansion of the TB-LAMP Application to HIV/TB Co-infections", by Dr. Nguyen Van HUNG, National Lung Hospital, Viet Nam
The content of this webinar is created and paid for by Eiken Chemical. All paid for sessions are reviewed for compliance with The Union’s mission and vision.
Product Information
If you have any question about using TB products, please refer to FAQ about TB LAMP. *This link will direct you to a website of HUMAN Gesellschaft für Biochemica und Diagnostica mbH (our distributor of TB products) .
Reference
- World Health Organization, The use of loop-mediated isothermal amplification (TB-LAMP) for the diagnosis of pulmonary tuberculosis: policy guidance, 2016.