Immunological and Serological Reagents “LZ Test Eiken”

About ABCD risk classification for gastric cancer

Gastric Cancer Risk Assessment Test (ABCD classification) is a method for determining the health status of the stomach of an individual by means of a combination of a pepsinogen test (as a gastric mucosal atrophy marker) and a Helicobacter pylori antibody test for screening H. pylori infections (considered to be the main cause of gastric ulcers, duodenal ulcers, and gastric cancers).

The number of unnecessary endoscopy can be reduced by prioritizing patients based on the risk group of gastric cancer.

The reduction of endoscopy examination to healthy people can contribute to decrease healthcare costs.

Pepsinogen (PG) test

It is a blood test designed to objectively evaluate the health status (degree of mucosal atrophy) of the stomach by measuring the serum concentration of a substance called “pepsinogen”. Many gastric cancer cases are shown to develop subsequent to gastric mucosal atrophy, the extent of which can be estimated using the pepsinogen test, and the test results can be utilized to screen individuals for increased risk of gastric cancer.

H. pylori antibody test

It is a screening test of H. pylori infections of gastric mucosa. When infected with H. pylori, the body produces antibodies against H. pylori (H. pylori antibodies) which are released into the blood. This antibody test is a method for measuring these H. pylori antibodies in the blood of the individual.

Product information

Reagents for automated analyzers

LZ Test 'Eiken' Series

LZ Test is a reagent for general-purpose fully automated analyzers based on the principle of latex agglutination immunoturbidimetry. Eiken Chemical developed and supplies products such as reagents for tests of atrophic gastritis - Pepsinogen I and II - and H.pylori Antibody.

Code No. Product Name IFU Product Description
V-IY05 LZ H.pylori Antibody Reagent PDF For detection of Helicobacter pylori antibodies in serum or plasma.
V-IY83 LZ H.pylori Antibody Calibrator PDF
V-IY84/85 LZ H.pylori Antibody Control-Low / High PDF
V-IZ51 LZ-PEPSINOGEN Ⅰ PDF For measurement of PepsinogenⅠ in serum or plasma.
V-IZ95 LZ-PG ⅠStandard PDF
V-IZ53 LZ-PEPSINOGEN Ⅱ PDF For measurement of PepsinogenⅡ in serum or plasma.
V-IZ96 LZ-PG ⅡStandard PDF
V-IZ97/98 PG-Control Low / High PDF For measurement of PepsinogenⅠ and Ⅱ in serum or plasma.

 *For IVD and CE marked

We have also experienced following immunoassays.

Rheumatoid factor (RF), Matrix metalloproteinase-3 (MMP-3), Serum amyloid A (SAA), C-reactive protein (CRP), Cystatin C, α1-microglobulin (α1-M), β2-microglobulin (β2-M), Urinary albumin, Prostate-specific antigen (PSA), Feritin, Krebs von den Lungen-6 (KL-6), Antibody for streptolysin O (ASO)

Featured Publications

  1. Miki K. Gastric cancer screening by combined assay for serum anti-Helicobacter pylori IgG antibody and serum pepsinogen levels - "ABC method". Proc Jpn Acad Ser B Phys Biol Sci. 2011;87(7):405-14.
  2. Yamaguchi Y, Nagata Y, Hiratsuka R, Kawase Y, Tominaga T, Takeuchi S, Sakagami S. Ishida S. Gastric Cancer Screening by Combined Assay for Serum Anti-Helicobacter pylori IgG Antibody and Serum Pepsinogen Levels - The ABC Method. Digestion. 2016;93(1):13-8.
  3. Saito S, Azumi M, Muneoka Y, Nishino K, Ishikawa, Sato Y, Terai S, Akazawa K. Cost-effectiveness of combined serum anti-Helicobacter pylori IgG antibody and serum pepsinogen concentrations for screening for gastric cancer risk in Japan. Eur J Health Econ. 2018 May;19(4):545-555.

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