TB Diagnostic Performance Comparison

Innovative Tool “TB LAMP”

TB LAMP is a manual molecular test to detect Mycobacterium Tuberculosis complex (MTBC).

It takes less than 1.5 hours to perform, requires minimal instrument in the form of a heating block, and generates a fluorescent result that can be detected with the naked eye.

Additionally, it has the potential for higher throughput as it can test up to 14 samples per test run (max. 70 samples per day). TB LAMP which is a simple, accurate, robust and affordable test, has been developed for use in high burden and resource limited settings.

TB-LAMP Detect TB. Accurately & Easily

TB-LAMP is ideally suited to make a credible impact onto the TB burden.

Rapid: First report (max. 14 sample) comes within 1.5 hours

Simple: All in one platform for extraction and detection. TB LAMP Operation >

Performance & Impact: WHO endorsed TB LAMP as a replacement of smear microscopy. Also about 100 papers are published. LAMP Publication list >

Scalable: TB LAMP is designed for medical care in remote rural areas  

Cost-effective: Cost of TB-LAMP is $ 6 (WHO target price). Announcement from Stop TB Partnership >

TB-LAMP vs Sputum Smear Microscopy

Sputum smear microscopy was a good solution; inexpensive and simple, quickly and easily.

However, the sensitivity is only about 50-60%.

TB-LAMP has some merits that cover that point:

Active Case Finding: Chest X-Ray + TB LAMP = Better Detection Rate

High sensitivity: Find more missing patients with TB

Turn Around Time: 70 samples/day & max. 14 samples/run

TB-LAMP vs Cartridge Based NAAT (CB-NAAT)

Cartridge Based Nucleic Acid Amplification Test (CB-NAAT) is a molecular technique that is used for detection of the presence of TB bacteria as well as testing for resistance to the drug Rifampicin.

TB-LAMP has some merits that can be compared with CB-NAAT:

Turn Around Time: 70 samples/day & max. 14 samples/run

Sample Volume: Only 60μl of sputum to perform TB-LAMP

References

  1. World Health Organization, The use of loop-mediated isothermal amplification (TB-LAMP) for the diagnosis of pulmonary tuberculosis: policy guidance, 2016.

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