New publication: Bovine mastitis and inflammation

New papers about bovine serum amyloid A (SAA) were published. Our immunoassay reagent "VET-SAA Eiken" is used for measurement of SAA.


Otsuka M, Nishi Y, Tsukano K, et al. Sequential changes in hepatic mRNA abundance and serum concentration of serum amyloid A in cattle with acute inflammation caused by endotoxin. J Vet Med Sci. 82(7): 1006–1011, 2020.  PubMed >

“Hepatic SAA2 and SAA4 mRNA abundance significantly increased from 4 hr after administration, and remained significantly higher than those pre-values up to 12 and 24 hr, respectively. [...] The major isotype was SAA2 in liver tissue, and it is indicating systemic inflammation in cattle.” (Otsuka et al. 2020)


Otsuka M, Sugiyama M, Ito T, et al. Diagnostic utility of measuring serum amyloid A with a latex agglutination turbidimetric immunoassay in bovine mastitis: comparison with haptoglobin and alpha 1 acid glycoprotein. J Vet Med Sci. ADVANCE ONLINE PUBLICATION. doi: 10.1292/jvms.20-0550  J-Stage >

"Only the plasma SAA concentration in cows with clinical mastitis (44.90 mg/l; n=15) was significantly higher than that in those with subclinical mastitis (10.70 mg/l; n=16), enabling their diagnosis in contrast to other APPs. Thus, the SAA assay using a LATIA reagent is useful in assessing mastitis severity due to its higher sensitivity and specificity than other APP assays." (Otsuka et al. 2020)

Related pages

Contact us

  Select a Topic
  First Name
  Last Name
  Email Address